Corticosteroids, colds, and mental health

Tapering down my corticosteroids and battling a run-of-the-mill cold while on immunosuppressants have left me exhausted this week.

Corticosteroids like prednisone are a first-line treatment for dermatomyositis and other autoimmune diseases but they can have serious side effects, especially when used over multiple months.
Corticosteroids like prednisone are a first-line treatment for dermatomyositis and other autoimmune diseases but they can have serious side effects, especially when used over multiple months.

Side effects of corticosteroids

No one should be on moderate to high doses prednisone or any corticosteroid for forever. Long-term corticosteroid use has several side effects: cataracts, bone loss, easy bruising, muscle weakness, weight gain, high blood sugar, psychosis, infection, and heart disease. People with healthy immune systems should not use them more than a couple weeks. Not unlike heroin detoxification, anyone who does use them for more than a few weeks has to taper down to lower and lower doses until you ween yourself off them.

Interestingly, even short-term steroid use has positive temporary side effects: namely, steroid euphoria. When you take the drug, you feel happy, positive, like you can conquer the world.

You can also have surpluses of energy, functioning on five to six hours of sleep just fine. I actually started this blog last July, during one of my steroid highs.

Corticosteroids screw with my mental health

As you taper down, each subsequent smaller dose deprives you of that drug-induced happiness. Much like someone weening themselves off opiates, you become physically depressed.

For almost nine months, my doctors have been varying doses of corticosteroids, trying to ween me off, only to put me back on moderate doses when my other medications fail.

This has been a mental and physical health nightmare, causing me to feel, at times, bipolar. One month, I get 30 or 40 mg of prednisone each day. The next, I taper down to 20 mg. At one point, I was on only 12.5 mg per day. Lately, I am down to 17.5 mg, leaving me feeling depressed.

Battling a common cold while suppressing my immune system

I also had a cold this week, my second of 2019 (the last ruined my New Year and my vacation). Just the usual symptoms: nasal congestion, ear and headaches, dehydration, fatigue.

Unlike people with healthy immune systems, my body seems to slow down more when I get sick. Several of my coworkers were still functioning the whole week while infected with the same virus, while I had to take a day and a half off work. Tuesday, I did nothing but watch YouTube videos of chef knife reviews. I have not been to the gym in a week. I ate junk food trying to make myself feel better.

Positive note: Even if immunosuppressants like methotrexate, azathioprine, and hydroxychloroquine leave me down for the count when a cold strikes, prednisone is like Aleve (naproxen) or Advil (ibuprofen) on steroids (pun intended). I barely notice nasal congestion or ear aches after I take prednisone in the morning. At night, however, I struggled to breathe normally.

I feel much better today, but now I have a new concern: a new, unexplained allergic reaction.

Depression: Don’t Be Afraid to Talk About It

An estimated 16.1 million Americans struggle with depression, according to the Anxiety and Depression Association of America. Few of those want to admit it. Fewer still want to talk about it.

Trying to explain the anguish and hopelessness inside you to those who have never battled mental illness is like a woman trying to explain the pain of childbirth to a man.

Sometimes people sense those overwhelming feelings of sadness, especially if you seem gloomy or unusually slow or uninterested in much of anything. But for many, such obvious signs are buried behind much more subtle symptoms. Some overeat. Some don’t eat at all. Many lose sleep. Others are always tired and sleep too much. More recently, psychologists have begun recognizing rage, anger, and irritability as symptoms of depression–especially in men, but also in women.

Trying to explain the anguish and hopelessness inside you to those who have never battled mental illness is like a woman trying to explain the pain of childbirth to a man.

Worse still, many turn to alcohol, drugs, work, and other addictions to bury their depression, anxiety, ADHD, or other mental disorders. When addictions cease to smother the pain, suicide becomes the last resort to make it all go away.

Depression and the American rock and metal scene

Among the most famous is Nirvana legend Kurt Cobain. A chronic drug and alcohol user since age 13, in 1986, he started using heroine. By 1990, recreation became addiction. Unlike softer drugs, repeated heroin use changes the brain’s structure and physiology, creating imbalances that are not easily reversed. Cobain’s brain became dependent on the drug, then developed a tolerance that made it almost impossible to ever deliver enough of the drug into his body to stay happy and alert. Eventually, overcome with mental, physical, and chemical depression, he shot himself.

Chris Cornell’s voice on Temple of the Dog’s “Hunger Strike” shows the pain he experienced most of his career that eventually killed him. The song is a favorite of mine and represents the best of grunge and has helped me get through some rough times.

Cobain is hardly alone among rockers and metalheads. Soundgarden and Audioslave frontman Chris Cornell struggled with depression most of his life until hanging himself in a Detroit hotel room at age 52.

Linkin Park’s Chester Bennington hung himself only months after Cornell, on what would have been Cornell’s 53rd birthday. Stone Temple Pilot’s Scott Weiland battled substance abuse for much of his career and a year and a half before Cornell died after overdosing on cocaine, ethanol, and methylenedioxyamphetamine (MDA).

At the core of these singers’ struggles, as a psychologist once taught me, are feelings of hopelessness. Little brings you happiness. Nothing seems to change. You feel trapped, perhaps useless, unwanted, unloved–even if you are adored by millions.

What causes us to feel hopeless?

Exactly what causes those feelings depends on the individual, but for many, myself included, we feel as though we are running from our pasts, from memories we long ago repressed, from demons we thought we exorcised on a therapist’s couch.

Some, like Cobain, have a family history of depression, suicide, and substance abuse, likely indicating an underlying physiological problem with the brain. For others, like Weiland, are simply unable to cope with terrible traumas and unprocessed memories of rape or abuse. Others still suffer from both.

Many have no idea most depressed people are in so much pain– even singers, musicians, writers, and artists whose lyrics, music, themes, and styles can be dramatic, morose, and hint at, if not signal mental anguish. Often, nobody knows until it’s too late. Our culture needs to change that.

Finding inspiration in those who have struggled

The past several months, I was inspired, though not surprised, to find these themes not just pop up, but humbly honored at rock and metal concerts. Dexter Holland of Offspring paid tribute to friends he lost. From Ashes to New dedicated multiple songs to Chester Bennington, citing him as a major influence and calling him a friend. Breaking Benjamin similarly called out struggles with suicide and depression. Five Finger Death Punch discussed substance abuse. Their lead vocalist, Ivan Moody, shared his own struggles and recent decision to stay sober.

Disturbed truly went out of their way, airing the numbers for mental health hotlines as they paid tribute to all that rock and metal have lost over the past few years to suicide or substance abuse as they played their ballad “A Reason to Fight.” While some have been critical of the track, calling it too much of a departure from Disturbed’s iconic twenty-first-century metal sound, I love the song. Hearing it live with candles and a supportive audience that clearly had many battling their own beasts inside.

Depression: You should talk about it. With the help of friends, family, therapy, medications, support groups, and hotlines, you can win the battle. I am proof of that.

In Disturbed’s words:

Don't let it take your soul, 
Look at me, take control
We're going to fight this war
This is nothing worth dying for

Are you ready to begin
This is a battle that we are gonna win